Drug delivery and antimicrobial studies of chitosan-alginate based hydroxyapatite bioscaffolds formed by the Casein micelle assisted synthesis

The present study aims to develop a hydroxyapatite (HAP) based scaffold composite for orthopaedic applications and that, we adopt Casein (Cs) micelle assisted synthesis route the formation of composite. Following characterization various fluorine (2% 5%) substituted HAPs (FHAP), they have been tested release Ciprofloxacin (CIP) drug antimicrobial efficacy. physicochemical such as FTIR Raman confirms successful HAP composites. Similarly, powder XRD FESEM analysis used confirmation crystallinity morphological behaviour, respectively. elemental composition has confirmed using EDX analysis. studies indicate that 5% FHAP sample is possessing superior antifungal antibacterial activities highest activity observed against gram-positive bacteria (Staphylococcus aureus) with an inhibition zone 47 mm while gram-negative (Escherichia coli) only 38 zone. CIP profile controlling Cs/5% sample. Therefore, this carried out use chitosan-alginate matrices. Further, chitosan-alginate/5% indicates porous, biodegradable, considerable water uptake retention ability, along maintenance controlled drug-releasing properties. Based on analysis, as-synthesized can be suitable biomedical bioengineering bone tissue growth implant.